β3 ar agonist brl 37344 sodium salt (Tocris)

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Tocris β3 ar agonist brl 37344 sodium salt

Vasorelaxant effects of β‐AR agonists in thoracic aorta from SHRs and wild‐type C57BL6 mice. The graphs illustrate the vasorelaxant responses of female and male aortic rings, with and without endothelium, to β‐AR agonists. Panel (A) shows the effects of the β 1 /β 2 ‐AR agonist isoprenaline and the β 3 ‐AR agonist <t>BRL‐37344</t> in female and male SHRs. Significant sex differences are observed in SHRs, and these differences are endothelium‐dependent, as removal of the endothelium abolishes the enhanced responses in females. Panel (B) depicts the effects of the same β‐AR agonists in female and male wild‐type mice, where no significant sex differences are detected, and endothelial removal has no measurable effect. Experiments were performed with n = 6 for both SHRs and wild‐type mice. All values are presented as mean ± SD. Panel (A) is created based on data from Al‐Gburi et al. .

β3 Ar Agonist Brl 37344 Sodium Salt, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 55 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/brl+37344/BRL+37344%2C+sodium+salt/pmc13128987-248-30-41
Average 93 stars, based on 55 article reviews

β3 ar agonist brl 37344 sodium salt - by Bioz Stars, 2026-09

93/100 stars

Images

1) Product Images from "Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue"

Article Title: Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Journal: Comprehensive Physiology

doi: 10.1002/cph4.70159

Figure Legend Snippet: Vasorelaxant effects of β‐AR agonists in thoracic aorta from SHRs and wild‐type C57BL6 mice. The graphs illustrate the vasorelaxant responses of female and male aortic rings, with and without endothelium, to β‐AR agonists. Panel (A) shows the effects of the β 1 /β 2 ‐AR agonist isoprenaline and the β 3 ‐AR agonist BRL‐37344 in female and male SHRs. Significant sex differences are observed in SHRs, and these differences are endothelium‐dependent, as removal of the endothelium abolishes the enhanced responses in females. Panel (B) depicts the effects of the same β‐AR agonists in female and male wild‐type mice, where no significant sex differences are detected, and endothelial removal has no measurable effect. Experiments were performed with n = 6 for both SHRs and wild‐type mice. All values are presented as mean ± SD. Panel (A) is created based on data from Al‐Gburi et al. .

Techniques Used:

other:

Article Title: Theobromine alleviates diet-induced obesity in mice via phosphodiesterase-4 inhibition.
Article Snippet: Purpose Modern science has given much attention to the treatment of obesity by activating brown adipose tissue (BAT) and browning of white adipose tissue (WAT).. Recent studies have identified theobromine, a derivative of cocoa, as a potent natural component actively browning white fat cells.. Here, we aimed to deduce the anti-obesity effect of theobromine involving phosphodiesterase (PDE) dependent-regulatory pathway in obese animal models.

Article Title: L-Dihydroxyphenylalanine (L-Dopa) Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via Activation of Dopaminergic and β3-adrenergic Receptors
Article Snippet: Due to its propensity to boost energy expenditure, browning of white fat is emerging as an intriguing and prospective target for therapeutic intervention in obesity.. Here, we report that L-dihydroxyphenylalanine (L-Dopa), used as a gold standard therapy in Parkinson's disease, induces browning in 3T3-L1 adipocytes by increasing the expression levels of beige-specific marker genes such as Cd137, Cited1, Cidea, Tbx1, Prdm16, and Ucp1.. In addition, exposure to L-Dopa induces a remarkable increase in the expressions of proteins involved in thermogenesis in white adipocytes.

Article Title: Colchicine stimulates browning via antagonism of GABA receptor B and agonism of β3-adrenergic receptor in 3T3-L1 white adipocytes.
Article Snippet: Colchicine has been used for therapeutic purposes and has attracted considerable attention because of its association with tubulin and the inhibition of small tubular polymerization.. Although several studies have examined the possible preventive role of colchicine in metabolic diseases, its role in adipocytes is largely unknown.. This study examined the novel functional role of colchicine in adipocytes demonstrating that colchicine stimulates browning in cultured white adipocytes.

Article Title: Trans -Cinnamic Acid Stimulates White Fat Browning and Activates Brown Adipocytes
Article Snippet: BRL 37344 and L-748.337 were purchased from Tocris Bioscience (Bristol, UK).

Article Title: Urolithin A Induces Brown-like Phenotype in 3T3-L1 White Adipocytes via β3-adrenergic Receptor-p38 MAPK Signaling Pathway
Article Snippet: Recently, pharmacological activation of thermogenesis in brown fat and induction of white fat browning (beiging) have been considered as promising strategies in the development of anti-obesity drugs.. During the screening of natural compounds that may stimulate thermogenesis, urolithin A (UroA), which is metabolized from pomegranate ellagitannins by gut microflora, was identified as a potent anti-obesity candidate.. In the present study, we elucidated the role of UroA to induce the brown-like phenotype in 3T3-L1 white adipocytes.

Expressing:

Article Title: Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
Article Snippet: .. Because beta-3 adrenergic receptor expression is weak in the normal rat heart, compounds were evaluated for the ability to attenuate the negative contractile effects of the beta-3 adrenergic receptor agonist BRL 37344 (Tocris Bioscience, Bristol, UK) in the normal rats. .. Because beta-3 adrenergic receptor expression is higher in the rat heart with CHF, a compound was evaluated for the ability to improve contractility compared to baseline in this CHF rat model. Myocardial infarction was induced in male Sprague-Dawley rats by performing left coronary descending artery ligation.

Concentration Assay:

Article Title: β 3 Relaxant Effect in Human Bladder Involves Cystathionine γ-Lyase-Derived Urothelial Hydrogen Sulfide.
Article Snippet: Tissues were stretched to a resting tension of 0.5 g and, after equilibration (60 min), were standardized via repeated carbachol (1 μM; Sigma, Italy) contractions [12]. .. A cumulative concentration–response curve for BRL 37344 (0.1–300 μM, Tocris, UK), a β3 AR selective agonist, was performed on strips pre-contracted with carbachol, in the presence or absence of urothelium. .. In another set of experiments, the strips were pretreated with DL-propargylglycine (PAG; 60 μL to reach 10 mM; Sigma, Milan, Italy) or aminooxy acetic acid (AOAA; 3 μL to reach 1 mM; Sigma, Milan, Italy), inhibitors for CSE and CBS, respectively, before the BRL 37344 challenge in the presence or absence of urothelium.

Article Title: β 3 Relaxant Effect in Human Bladder Involves Cystathionine γ-Lyase-Derived Urothelial Hydrogen Sulfide
Article Snippet: Tissues were stretched to a resting tension of 0.5 g and, after equilibration (60 min), were standardized via repeated carbachol (1 μM; Sigma, Italy) contractions [ ]. .. A cumulative concentration–response curve for BRL 37344 (0.1–300 μM, Tocris, UK), a β 3 AR selective agonist, was performed on strips pre-contracted with carbachol, in the presence or absence of urothelium. .. In another set of experiments, the strips were pretreated with DL-propargylglycine (PAG; 60 μL to reach 10 mM; Sigma, Milan, Italy) or aminooxy acetic acid (AOAA; 3 μL to reach 1 mM; Sigma, Milan, Italy), inhibitors for CSE and CBS, respectively, before the BRL 37344 challenge in the presence or absence of urothelium.

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